RyClora

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 8/4/2022

Drug Summary

What Is RyClora?

RyClora (dexchlorpheniramine maleate liquid) is an antihistamine used to treat perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of hives and angioedema, amelioration of allergic reactions to blood or plasma, dermographism, and as therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.

What Are Side Effects of RyClora?

Side effects of RyClora include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for RyClora

The recommended dosage of RyClora for adults and children 12 years of age and older is 2 mg (1 teaspoonful); for children 6 to 11 years: 1 mg (1/2 teaspoonful); and for children 2 to 5 years: 0.5 mg (1/4 teaspoonful)/ Doses are generally given every 4 to 6 hours.

RyClora In Children

In infants and children, especially, antihistamines in overdosage may cause hallucinations, convulsions, or death.

As in adults, antihistamines may diminish mental alertness in children. In the young child, particularly, they may produce excitation.

What Drugs, Substances, or Supplements Interact with RyClora?

RyClora may interact with other medicines such as:

  • monoamine oxidase inhibitors (MAOIs)

Tell your doctor all medications and supplements you use.

RyClora During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using RyClora; it is unknown how it would affect a fetus. Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, antihistamine therapy with RyClora is not recommended while breastfeeding.

Additional Information

Our RyClora (dexchlorpheniramine maleate liquid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Description for RyClora

Each 5 mL (Teaspoonful) Contains

Dexchlorpheniramine Maleate, USP 2 mg

Dexchlorpheniramine Maleate, USP, an antihistamine agent, is a white, odorless crystalline powder that is freely soluble in water. The molecular formula is C16H19ClN2· C4H4O4, designated chemically as (+)-2-[p-Chloro-α- [2-(dimethylamino)ethyl]benzyl] pyridine maleate (1:1).

RYCLORA™ (dexchlorpheniramine maleate) Structural Formula Illustration

M.W. = 390.86

Inactive Ingredients

Citric acid, cherry flavoring, FD&C Red No. 40, glycerin, menthol, methylparaben, propylene glycol, propylparaben, purified water, sodium citrate dihydrate, and sugar.

Uses for RyClora

Perennial and seasonal allergic rhinitis

Vasomotor rhinitis

Allergic conjunctivitis due to inhalant allergens and foods

Mild, uncomplicated allergic skin manifestations of urticaria and angioedema

Amelioration of allergic reactions to blood or plasma

Dermographism

As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.

Dosage for RyClora

DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.

Recommended Dosage

Adults and Children 12 years of age and older: 2 mg (1 teaspoonful)

Children 6 to 11 years: 1 mg (1/2 teaspoonful)

Children 2 to 5 years: 0.5 mg (1/4 teaspoonful)

Doses are generally given every 4 to 6 hours.

HOW SUPPLIED

RYCLORA™ Oral Solution is supplied as a red colored, cherry flavored liquid in the following sizes:

4 fl oz (118 mL), NDC 15370-150-04
16 fl oz (473 mL), NDC 15370-150-16
0.7 fl oz (20mL), NDC 15370-150-99 (as physician sample)

Recommended Storage

Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].

Dispense in a tight, light-resistant container as defined in the USP, with child-resistant closure.

Manufactured for: Carwin Pharmaceutical Associates, LLC, Hazlet, NJ 07730. Revised: Mar 2018

Side Effects for RyClora

  1. General: Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of mouth, nose and the throat.
  2. Cardiovascular System: Hemolytic anemia, thrombocytopenia, agranulocytosis.
  3. Hematologic System: Hemolytic anemia, thrombocytopenia, agranulocytosis.
  4. Nervous System: Sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesias, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, hysteria, neuritis, convulsions.
  5. G.I. System: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation.
  6. G.U. System: Urinary frequency, difficult urination, urinary retention, early menses.
  7. Respiratory System: Thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness.

Call your doctor for medical advice about side effects. You may voluntarily report side effects to FDA at 1-800-FDA-1088. Questions or comments? Call Carwin Pharmaceutical Associates, LLC at 1-844-700-5011.

Drug Interactions for RyClora

MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines.

Warnings for RyClora

Antihistamines should be used with considerable caution in patients with:

Narrow angle glaucoma
Stenosing peptic ulcer
Pyloroduodenal obstruction
Symptomatic prostatic hypertrophy
Bladder neck obstruction

Use In Children

In infants and children, especially, antihistamines in overdosage may cause hallucinations, convulsions, or death.

As in adults, antihistamines may diminish mental alertness in children. In the young child, particularly, they may produce excitation.

Use In Pregnancy

Experience with this drug in pregnant women is inadequate to determine whether there exists a potential for harm to the developing fetus.

Use With CNS Depressants

RYCLORA™ Oral Solution has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc.).

Use In Activities Requiring Mental Alertness

Patients should be warned about engaging in activities requiring mental alertness such as driving a car or operating appliances, machinery, etc.

Use In The Elderly (Approximately 60 Years Or Older)

Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients.

Precautions for RyClora

RYCLORA™ Oral Solution has an atropine-like action and, therefore, should be used with caution in patients with:

History of bronchial asthma
Increased intraocular pressure Hyperthyroidism
Cardiovascular disease
Hypertension

Overdose Information for RyClora

Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in children. Atropine-like signs and symptoms—dry mouth, fixed, dilated pupils, flushing, and gastrointestinal symptoms may also occur.

If vomiting has not occurred spontaneously the patient should be induced to vomit. This is best done by having the patient drink a glass of water or milk after which the patient should be made to gag. Precautions against aspiration must be taken, especially in infants and children.

Saline cathartics, such as milk of magnesia, draw water into the bowel by osmosis and therefore, are valuable for their action in rapid dilution of bowel content.

Stimulants should not be used.

Vasopressors may be used to treat hypotension.

Contraindications for RyClora

Use In Newborn Or Premature Infants

This drug should not be used in newborn or premature infants.

Use In Nursing Mothers

Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.

Use In Lower Respiratory Disease

Antihistamines should NOT be used to treat lower respiratory tract symptoms including asthma.

Antihistamines are also contraindicated in the following conditions:

Hypersensitivity to dexchlorpheniramine maleate or other antihistamines of similar chemical structure
Monoamine oxidase inhibitor therapy (See DRUG INTERACTIONS)

Clinical Pharmacology for RyClora

Dexchlorpheniramine maleate is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.

Patient Information for RyClora

No information provided. Please refer to the WARNINGS AND PRECAUTIONS section.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.