Are Skyrizi and Otezla the Same Thing?
Skyrizi (risankizumab-rzaa) and Otezla (apremilast) are used to treat different types of psoriasis.
Skyrizi is used to treat moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Otezla is used to treat adult patients with active psoriatic arthritis.
Skyrizi and Otezla belong to different drug classes. Skyrizi is an interleukin-23 antagonist and Otezla is a phosphodiesterase 4 (PDE4) inhibitor.
Side effects of Skyrizi and Otezla that are similar include upper respiratory infections, headache, and fatigue.
Side effects of Skyrizi that are different from Otezla include injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth) and tinea infections (such as ringworm, athlete's foot, and jock itch).
Side effects of Otezla that are different from Skyrizi include diarrhea, nausea, vomiting, runny or stuffy nose, abdominal pain, indigestion/heartburn, decreased appetite, insomnia, back pain, frequent bowel movements, depression, bronchitis, tooth abscess, sinus headache, weight loss, gastroesophageal reflux disease (GERD), migraine, cough, and rash.
Skyrizi may interact with "live" vaccines.
Otezla may interact with CYP450 inducers (such as rifampin, phenobarbital, carbamazepine, and phenytoin).
What Are Possible Side Effects of Skyrizi?
Side effects of Skyrizi include:
- upper respiratory infections,
- headache,
- fatigue,
- injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth), and
- tinea infections (such as ringworm, athlete's foot and jock itch)
What Are Possible Side Effects of Otezla?
Common side effects of Otezla include:
- diarrhea,
- headache,
- nausea,
- upper respiratory tract infection,
- vomiting,
- runny or stuffy nose,
- abdominal pain,
- fatigue,
- indigestion/heartburn,
- decreased appetite,
- insomnia,
- back pain,
- frequent bowel movements,
- depression,
- bronchitis,
- tooth abscess, and
- sinus headache.
What Is Skyrizi?
Skyrizi (risankizumab-rzaa) is an interleukin-23 antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
What Is Otezla?
Otezla (apremilast) is a phosphodiesterase 4 (PDE4) inhibitor used to treat adult patients with active psoriatic arthritis.
What Drugs Interact With Skyrizi?
Skyrizi may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Skyrizi; it is unknown how it would affect a fetus. It is unknown if Skyrizi passes into breast milk. Consult your doctor before breastfeeding.
How Should Skyrizi Be Taken?
The dose of Skyrizi is 150 mg (two 75 mg injections) administered by subcutaneous injection at Week 0, Week 4 and every 12 weeks thereafter.
From 
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AbbVie Inc. Skyrizi Product Information.
https://www.skyrizi.com
Abbvie. Humira Product Monograph.
https://www.humira.com/