Inflectra vs. Remicade

Inflectra (infliximab-dyyb) for Injection and Remicade (infliximab) are used to reduce signs and symptoms of Crohn's disease, pediatric Crohn's disease, ulcerative colitis, rheumatoid arthritis (in combination with methotrexate), ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis.

Remicade is often used when other medicines have not been effective.

Inflectra and Remicade belong to different drug classes. Inflectra is a tumor necrosis factor (TNF) blocker and Remicade) is a chimeric IgG1k monoclonal antibody.

Side effects of Inflectra and Remicade that are similar include runny or stuffy nose, headache, stomach/abdominal pain, nausea, and skin rash.

Side effects of Inflectra that are different from Remicade include upper respiratory infections, sinus infections, bronchitis, sore throat, cough, infusion-related reactions, indigestion, diarrhea, itching, fatigue, pain, fever, oral thrush, joint pain, urinary

tract infection (UTI), and high blood pressure (hypertension).

Side effects of Remicade that are different from Inflectra include sinus pain and flushing (warmth, redness, or tingly feeling).

Both Inflectra and Remicade may interact with anakinra, abatacept, tocilizumab, other biological therapeutics used to treat the same conditions, and "live" vaccines.

Inflectra may also interact with warfarin, cyclosporine, and theophylline.

Remicade may also interact with other medicines to treat Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and psoriasis.

Common side effects of Inflectra include:

• upper respiratory infections
• sinus infections
• runny or stuffy nose
• sore throat
• cough
• bronchitis
• infusion-related reactions
• headache
• abdominal pain
• nausea
• diarrhea
• indigestion
• rash
• itching
• fatigue
• pain
• fever
• oral thrush
• joint pain
• urinary tract infection, and
• high blood pressure (hypertension)

Common side effects of Remicade include:

• headache,
• stomach pain,
• nausea,
• stuffy nose,
• sinus pain,
• skin rash, or
• flushing (warmth, redness, or tingly feeling).

Tell your doctor if you experience serious side effects of Remicade including:

• pain or swelling at injection site,
• joint or muscle pain,
• swelling of ankles or feet,
• easy bruising or bleeding,
• vision changes,
• seizures,
• confusion,
• muscle weakness,
• numbness and tingling of arms or legs,
• butterfly-shaped facial rash,
• chest pain,
• pain/redness/swelling of arms or legs,
• shortness of breath, or
• fast/slow/irregular heartbeat.

Inflectra (infliximab-dyyb) for Injection is a tumor necrosis factor (TNF) blocker indicated for reducing signs and symptoms of Crohn's disease, pediatric Crohn's disease, ulcerative colitis, rheumatoid arthritis (in combination with methotrexate), ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis.

Remicade (infliximab) is a chimeric IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. Remicade is also used to treat severe or disabling plaque psoriasis (raised, silvery flaking of the skin). Remicade is often used when other medicines have not been effective. Remicade blocks the action of a protein in your body called tumor necrosis factor-alpha (TNF-alpha).

Inflectra may interact with anakinra, abatacept, tocilizumab, other biological therapeutics used to treat the same conditions, warfarin, cyclosporine, theophylline, or "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. During pregnancy, Inflectra should be administered only if prescribed. It is unknown if it would affect a fetus. It is unknown if Inflectra passes into breast milk. Because of the potential for unwanted effects on a nursing infant, breastfeeding while using Inflectra is not recommended.

Other drugs may interact with Remicade. Tell your doctor all prescription and over-the-counter medications and supplements you use.

Inflectra is administered by intravenous infusion and the dose is based on the patient's weight and the condition being treated.

The dosing of Remicade varies, and depends on the condition being treated.