Humira vs. Hyrimoz

Humira (adalimumab) and Hyrimoz (adalimumab-ad az) are types of monoclonal antibodies called tumor necrosis factor (TNF)-blockers used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and Crohn's disease.

Hyrimoz is biosimilar to Humira.

Side effects of Humira and Hyrimoz that are similar include injection site reactions (redness, itching, pain, bruising, swelling, or bleeding), headache, and stomach/abdominal pain.

Side effects of Humira that are different from Hyrimoz include stuffy nose and sinus pain.

Side effects of Hyrimoz that are different from Humira include infections (e.g. upper respiratory tract infection, sinusitis, urinary tract infection), rash, nausea, and hypertension (high blood pressure).

Both Humira and Hyrimoz may interact with abatacept, anakinra, and live vaccines such as measles/mumps/rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Humira may also interact with etanercept, azathioprine, mercaptopurine, and monoclonal antibodies.

Hyrimoz may also interact with warfarin, cyclosporine, and theophylline.

Side effects of Humira include:

• injection site reactions (redness, itching, pain, bruising, swelling, or bleeding),
• headache,
• suffy nose,
• sinus pain, or
• stomach pain.

Tell your doctor if you have serious side effects of Humira including:

• fast/irregular/pounding heartbeat,
• stomach pain,
• blood in the stools,
• mental/mood changes,
• severe headache,
• easy bruising or bleeding,
• dark urine,
• yellowing eyes and skin,
• leg pain or swelling,
• numbness or tingling of the arms/hands/legs/feet,
• unsteadiness,
• unexplained muscle weakness,
• difficulty with speaking/chewing/swallowing/facial movements,
• vision changes,
• extreme fatigue,
• joint pain, or
• butterfly-shaped rash on the nose and cheeks.

Common side effects of Hyrimoz include:

• infections (e.g. upper respiratory tract infection, sinusitis, urinary tract infection),
• injection site reactions (redness, itching, bleeding, pain or swelling),
• headache,
• rash,
• nausea,
• abdominal pain, or
• hypertension (high blood pressure)

Humira (adalimumab) is an injectable protein (antibody) used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. Humira is also used to treat Crohn's disease after other drugs have been tried without successful treatment of symptoms.

Hyrimoz (adalimumab-ad az) is a tumor necrosis factor (TNF)-blocker biosimilar to Humira (adalimumab) indicated for treatment of rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease, ulcerative colitis (UC), and plaque psoriasis.

Humira may interact with azathioprine or mercaptopurine. Asacol may also interact with pentamidine, tacrolimus, amphotericin B, antibiotics, antiviral medicines, cancer medicine, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs).

Humira may also interact with abatacept, anakinra, infliximab, etanercept, certolizumab pegol, golimumab, or rituximab.

Hyrimoz may interact with abatacept, anakinra, warfarin, cyclosporine, theophylline, and live vaccines.

Humira is given by an injection under the skin. Your doctor will tell you how often to take an injection of Humira. This is based on your condition to be treated. Do not inject Humira more often than you were prescribed.

Do not try to inject Humira yourself until you have been shown the right way to give the injections. If your doctor decides that you or a caregiver may be able to give your injections of Humira at home, you should receive training on the right way to prepare and inject Humira.

Do not miss any doses of Humira unless your doctor says it is okay. If you forget to take Humira, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time. This will put you back on schedule.

In case you are not sure when to inject Humira, call your doctor or pharmacist.

If you take more Humira than you were told to take, call your doctor.

The dose of Hyrimoz depends on the condition being treated.