Are Duobrii and Skyrizi the Same Thing?
Duobrii (halobetasol propionate and tazarotene) Lotion and Skyrizi (risankizumab-rzaa) are used to treat plaque psoriasis in adults.
Duobrii Lotion is a topical (for the skin) treatment and Skyrizi is given as a subcutaneous injection.
Duobrii and Skyrizi belong to different drug classes. Duobrii is a combination of a corticosteroid and a retinoid and Skyrizi is an interleukin-23 antagonist.
Side effects of Duobrii that are different from Skyrizi include contact dermatitis, application site pain, infected hair follicles, thinning skin, skin abrasions, rash, stretch marks, and skin peeling.
Side effects of Skyrizi that are different from Duobrii include upper respiratory infections, headache, fatigue, injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth), and tinea infections (such as ringworm, athlete's foot and jock itch)
Duobrii may interact with corticosteroids taken by mouth or injection and other products used on your skin that contain corticosteroids.
Skyrizi may interact with "live" vaccines.
What Are Possible Side Effects of Duobrii?
Common side effects of Duobrii include:
- contact dermatitis,
- application site pain,
- infected hair follicles,
- thinning skin,
- skin abrasions,
- rash,
- stretch marks, and
- skin peeling
What Are Possible Side Effects of Skyrizi?
Common side effects of Skyrizi include:
- upper respiratory infections,
- headache,
- fatigue,
- injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth), and
- tinea infections (such as ringworm, athlete's foot and jock itch)
What Is Duobrii?
Duobrii (halobetasol propionate and tazarotene) Lotion is a combination of a corticosteroid and a retinoid indicated for the topical treatment of plaque psoriasis in adults.
What Is Skyrizi?
Skyrizi (risankizumab-rzaa) is an interleukin-23 antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
What Drugs Interact With Duobrii?
Duobrii Lotion may interact with corticosteroids taken by mouth or injection, or other products used on your skin that contain corticosteroids. Tell your doctor all medications and supplements you use. Duobrii Lotion is not recommended for use during pregnancy; it may harm a fetus. A negative result for pregnancy should be obtained within 2 weeks prior to Duobrii Lotion therapy, which should begin during menstruation. Females of reproductive potential are advised to use effective contraception during treatment with Duobrii Lotion. It is unknown if Duobrii passes into breast milk.
What Drugs Interact With Skyrizi?
Skyrizi may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Skyrizi; it is unknown how it would affect a fetus. It is unknown if Skyrizi passes into breast milk. Consult your doctor before breastfeeding.
How Should Duobrii Be Taken?
Apply a thin layer dose of Duobrii Lotion to the affected areas once daily.
From 
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https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209354s000lbl.pdf
AbbVie Inc. Skyrizi Product Information.
https://www.skyrizi.com