How Do Streptogramins Work?

Streptogramins are a class of antibiotics that work by inhibiting the synthesis of protein in bacteria. There are two types of streptogramins: streptogramin A (dalfopristin) and streptogramin B (quinupristin). Individually, both A and B streptogramins inhibit bacterial growth (bacteriostatic). However, when combined, streptogramins A and B kill bacteria (bactericidal).

Streptogramins are mainly effective against gram-positive bacteria. They are mainly used for the treatment of:

• Skin infections
• Bacteremia (presence of bacteria in the bloodstream)
• Intravascular catheter-associated bacteremia (catheter-related bloodstream infection)

Some of the most reported side effects of streptogramins include:

• Pain
• Inflammation at site of injection
• Hyperbilirubinemia (excess buildup of bilirubin in the blood)
• Edema at the injection site
• Allergy at the infusion site

Some of the less common side effects of streptogramins include:

• Nausea
• Vomiting
• Joint pain
• Muscle pain
• Anemia
• Headache
• Diarrhea
• Rash
• Itching
• Thrombophlebitis (inflammation of a vein, usually in the leg)

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Streptogramin drug names include:

• Quinupristin/dalfopristin
• Synercid