What Is Osteoporosis? Treatment, Symptoms, Medication

Osteoporosis is a disorder of the bones in which the bones become brittle, weak, and easily damaged or broken. A decrease in the mineralization and strength of the bones over time causes osteoporosis.

While the effects of osteoporosis are often seen in the elderly, the disorder usually starts progressing from middle age on. Bones are their strongest in a person's mid-twenties, so it is important to have a good foundation early on to maintain healthy bones late in life.

In the United States, 10 million people have osteoporosis (80% of those are women), and 44 million are at risk for developing the disease due to low bone density. Osteoporosis is a public health issue in the U.S. because the disease contributes to two million fractures (broken bones), including 300,000 hip fractures, annually. The costs of medical care for these injures is an estimated $19 billion annually. These injuries can also result in permanent disability or an inability to return to work or perform daily activities.

Osteoporosis may not cause any apparent symptoms. People may not know they have osteoporosis until they break (fracture) a bone.

Vertebral (spinal) compression fractures are broken bones in the back that are due to weak bones caused by osteoporosis. The vertebrae (spinal bones) collapse as a result of even minor injuries related to falling, bending, twisting, or sneezing. As the bones of the spine lose their mineralization and strength, they can collapse, causing a hunched-over appearance, often referred to as a "dowager hump."

Stress fractures occur in bones due to repetitive injuries, usually with minimal trauma. People with osteoporosis are more prone to stress fractures because of the weakness of their bones.

Those affected by osteoporosis are at greater risk for hip fractures. Even a simple fall can cause a hip fracture in a person with osteoporosis. Due to the weakness in the bones these injuries may take a long time or be difficult to fully heal.

Fractures related to osteoporosis can result in significant pain and disability. Hip fractures are common among people with osteoporosis. Approximately 24 percent of hip fracture patients over the age of 50 die within one year following their injury, and one-quarter will remain in a nursing home.

Those who have one vertebral (spinal) compression fracture are at high risk for developing other such fractures.

Bone strength is related to bone mass (density), which refers to the amount of mineralization remaining in bones as people age. The denser the bones, the stronger they are.

Factors that determine bone strength include:

• Genetics
• Environment
• Medications
• Ethnicity (African-Americans have higher bone density than Caucasians or Asians)
• Gender (men have higher bone density than women)
• Aging (bone density reaches its peak around age 25, and decreases after age 35)

Women tend to be diagnosed with osteoporosis more often than men because once they reach menopause, estrogen levels decrease. Estrogen helps maintain bone density in women. Post-menopausal women can lose up to 20 percent of bone mass during the five to seven years following menopause.

Risk factors for developing osteoporosis that cannot be controlled include:

• Female gender
• Ethnicity – Caucasian or Asian
• Family history

Risk factors for developing osteoporosis that can be controlled include:

• Smoking
• Lack of exercise
• Diets lacking calcium
• Poor nutrition
• Alcohol abuse

Additional risk factors for developing osteoporosis include medical conditions such as:

• Chronically low estrogen levels
• Vitamin D deficiency
• Hyperthyroidism
• Inability to exercise
• Medications, such as chemotherapy, corticosteroids, or seizure medications
• Hyperparathyroidism
• Loss of menstrual periods (amenorrhea)
• Inability to absorb nutrients properly in the digestive tract

Osteoporosis is often diagnosed on an X-ray when the patient suffers a fracture. However, by the time osteoporosis is visible on X-ray there may be significant bone loss.

A dual energy X-ray absorptiometry (DEXA or DXA) scan can be used as a screening test for osteopenia (bone loss that precedes osteoporosis). This test measures bone density in the hip and spine and is more precise than an X-ray.

The National Osteoporosis Foundation recommends the following groups of people should have dual energy X-ray absorptiometry (DEXA or DXA) scans to screen for osteoporosis:

• All women age 65 and older
• All postmenopausal women under age 65 who have risk factors for osteoporosis
• Postmenopausal women with fractures
• • Women with a medical condition associated with osteoporosis, including rheumatoid arthritis, smoking, alcoholism, or body weight less than 127 pounds.

The DXA scan lists results as a "T score." This measurement is a statistical comparison (SD, or standard deviation) of the patient's bone density compared to the average peak bone density of a young adult of the same gender and ethnicity.

• A T score of -1 to -2.5 SD is characteristic of osteopenia, which is a precursor to osteoporosis
• A T score of -2.5 SD or below indicates osteoporosis

There is no current cure for osteoporosis. Osteoporosis treatment involves stopping further bone loss and strengthening bones that show signs of weakness. Prevention of osteoporosis is key. Exercise before menopause helps increase bone mass. After menopause, exercise slows the rate of bone loss. Most doctors recommend that healthy people get 150 minutes of physical activity every week. That corresponds to 30-minute workouts on most days of the week.

Exercise is important in helping improve muscle strength and balance, which can decrease falls and other accidents. Weight-bearing exercise also has the benefit of helping to strengthen bones. Weight-bearing exercises are activities in which your bones and muscles must work against gravity. Walking and working out with weights are two examples of weight-bearing exercises. Consult your doctor for the type and duration of exercise that is right for you.

In people with osteoporosis, exercise may injure weakened bones. It is important to discuss with a health care practitioner the exercises that are appropriate for people with osteoporosis. It is also important to consider other medical problems that may also be present (heart disease, diabetes, high blood pressure) before starting any exercise program. Some types of extreme exercise such as marathon running may not be recommended for people with osteoporosis.

Smoking can result in bone loss. In people with osteoporosis this can accelerate the progression of the disease. It also decreases estrogen levels in women, which can lead to earlier menopause, and further bone loss.

The effect of alcohol and caffeine on osteoporosis is not clear. To maintain optimal heath, consume alcohol and caffeine in moderation.

Calcium intake is important for strong and healthy bones. Adequate calcium intake must occur earlier in life to help prevent osteopenia and osteoporosis.

The Food and Nutrition Board (FNB) of the Institute of Medicine of the National Academies has established intake recommendations for nutrients, including calcium. These recommendations vary by age and gender as shown here.

Good sources of dietary calcium include dairy products, vegetables (kale, cabbage, broccoli, spinach), and fortified foods (fruit juices, non-dairy milks, cereals). Postmenopausal women may need more calcium.

Most Americans do not get enough of the U.S. Recommended Daily Allowance (USRDA) of calcium. Some examples of dietary sources of calcium include milk, yogurt, cheese, and fortified orange juice.

In order to properly absorb calcium in the diet and maintain good bone health, the body also needs vitamin D for the following:

• Absorption of calcium from the intestines
• Prevention of osteomalacia, which can further weaken bones
• Increase bone density and decrease fractures in postmenopausal women

The USRDA for vitamin D is 600 IU (international units) per day for children age 1 year up to adults of 70 years. Infants under 1 year need 400 IU, while adults 71 and older require 800 IU.

Good sources of vitamin D include sunlight, fatty fish such as salmon or mackerel, beef liver, egg yolk, milk or orange juice fortified with vitamin D, fortified cereals, and infant formulas.

Because estrogen can play a role in maintaining bone density and strength in women, some post-menopausal women with osteoporosis are prescribed hormone therapy (menopausal hormone therapy, formerly referred to as hormone replacement therapy, or HRT) to prevent bone loss and fractures.

Estrogen may be prescribed alone orally (Premarin, Estrace, Estratest) or as a skin patch (Estraderm, Vivelle), or along with progesterone. The combination of the two hormones can help prevent uterine cancer that can result from using estrogen alone. Post-menopausal hormone therapy can have side effects including increased risk of heart attack, stroke, blood clots, and breast cancer so it is not typically recommended for long-term use. Consult a doctor for more information on hormone therapy.

There are several types of medications used to treat osteoporosis. Your doctor considers your sex, age, health conditions and other factors along with osteoporosis treatment guidelines to determine which medication is right for you.

1. Anti-resorptive drugs: These medications prevent bone resorption (breakdown) and can help increase bone mass. Examples include alendronate (Fosamax, Binosto), risedronate (Actonel), raloxifene (Evista), ibandronate (Boniva), risedronate (Atelvia), calcitonin (Calcimar), and zoledronate (Reclast). RANK ligand (RANKL) inhibitors like denosumab (Prolia) are in this class. So are calcitonin (Fortical, Miacalcin) and tissue specific estrogen complex (TSEC) like estrogen/bazodoxifene (Duavee).

2. Post-menopausal estrogen hormone therapy: this can act much as the anti-resorptive drugs do, preventing bone loss and helping increase bone mass.

3. Selective estrogen receptor modulators (SERMs): These medications work like estrogen, and include tamoxifen and Raloxifene (Evista).

4. Anabolic drugs: these are the only drugs that actually build bone mass. Teriparatide, a form of parathyroid hormone, is one example of this type of drug. Sclerostin inhibitors like romosozumab-aqqg (Evenity) and parathyroid hormone-related protein (PTHrp) analog like abaloparatide (Tymlos) are also in this class.

Hip protectors can reduce the risk of hip fractures in people who have osteoporosis and are at risk for falls. Hip protectors are undergarments with thin layers of foam or plastic on the hips. Hipsaver and Safehip are two of the brands available.

• Osteoporosis is a disorder of the bones in which the bones become brittle, weak, and easily damaged or broken.
• Bone mass (bone density) reaches its peak between the sages of 25 and 30, and decreases after the age of 40 and decreases more rapidly in women after menopause.
• Risk factors for osteoporosis include genetics, lack of exercise, lack of calcium and vitamin D, cigarette smoking, excessive alcohol consumption, and family history of osteoporosis.
• People with osteoporosis may have no symptoms until bone fractures occur.
• Osteoporosis may be diagnosed using X-rays but it is more likely to be detected with DEXA scans which measure bone density.
• Treatments for osteoporosis include prescription osteoporosis medications, quitting smoking, and getting appropriate exercise, calcium, and vitamin D.